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Fibrodysplasia Ossificans Progressiva is a disease where the body’s repair mechanism is completely broken, and starts “healing” the fibrous tissue (muscles, tendons and ligaments) by turning them into bone. Your whole body is slowly being petrified. There’s no known treatment for the 450 sufferers worldwide, and in one famous case a sufferer survived up to the age 40, at which point his entire body, except his lips and transformed into bone, leaving him completely immobile.
Skull with leontiasis ossea ("Lion face"). This rare condition is symptomatic of several diseases including fibrous dysplasia, Paget's disease, hyperparathyroidism, syphilitic osteoperiostitis and renal osteodystrophy. The condition is characterized by an overgrowth of bone (hyperostosis) in the facial and cranial bones.
A female skull dating from 1829 with the bony skeleton of a large facial tumour (possibly caused by neurofibromatosis) involving the right side of the face. The tumour arose in the right antrum, and during five years’ growth destroyed the right malar bone, the palate, and the maxilla. Specimen from the Hunterian Museum of the Royal College of Surgeons, London.